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Fluoxetine + Tramadol
Can you take these together?

🇺🇸 Based on FDA Data · Free
🚨
Do Not Combine
Fluoxetine + Tramadol

These medications are contraindicated. Do not take together without medical supervision.

📊 Data Sources
🇺🇸FDA openFDA API — Drug interaction data sourced from the U.S. Food & Drug Administration's official drug label database (openFDA). The same data used by U.S. healthcare professionals. FDA official site →
🇰🇷MFDS DUR API (Korea) — Contraindication data from South Korea's Ministry of Food and Drug Safety (MFDS) Drug Utilization Review public API. Covers 44,000+ medications. MFDS official site →

⚕️ This information is for reference only and does not constitute medical advice. Always consult a doctor or pharmacist before taking medications.

🔍 Check Another Combination
💊 Drug Information
SSRI AntidepressantFluoxetine(Fluoxetine (Prozac, Sarafem))

Fluoxetine (Prozac) is a widely used SSRI antidepressant with a uniquely long half-life that distinguishes it from other SSRIs in terms of drug interactions and discontinuation effects.

🔬 How It Works

Fluoxetine selectively inhibits serotonin reuptake and is a potent inhibitor of CYP2D6, meaning it can significantly raise blood levels of medications metabolized by that enzyme.

💡 Common Uses
  • Major depressive disorder
  • OCD
  • Panic disorder
  • Bulimia nervosa
  • Bipolar depression (with mood stabilizer)
⚡ Side Effects
  • Nausea, insomnia, headache (early)
  • Sexual dysfunction
  • Anxiety or agitation initially
  • Long washout period due to long half-life
⚠ Caution: Long half-life means interactions persist weeks after stopping. Serotonin syndrome risk. Potent CYP2D6 inhibitor.
Opioid AnalgesicTramadol(Tramadol (Ultram))

Tramadol is a prescription opioid analgesic used for moderate to moderately severe pain. It also inhibits serotonin and norepinephrine reuptake, creating complex drug interaction risks.

🔬 How It Works

Tramadol acts as a weak mu-opioid receptor agonist and also inhibits serotonin and norepinephrine reuptake (similar to SNRIs). Its dual mechanism creates unique interactions with both opioid and antidepressant medications.

💡 Common Uses
  • Moderate to moderately severe pain
  • Post-surgical pain
  • Chronic pain management
  • Neuropathic pain (off-label)
⚡ Side Effects
  • Nausea, dizziness, constipation
  • Drowsiness and impaired coordination
  • Seizure risk (especially with SSRIs or SNRIs)
  • Physical dependence and withdrawal
  • Serotonin syndrome risk (with SSRIs, SNRIs, MAOIs)
⚠ Caution: Serotonin syndrome risk with antidepressants. Seizure risk. Avoid alcohol. Dependence potential.

💊 Drug Interaction Safety Guide

What is a Drug Interaction?

A drug interaction occurs when one medication affects the activity of another when taken simultaneously. This can increase or decrease the effectiveness of a drug, or cause unexpected side effects. Over-the-counter medications, supplements, and even foods can also interact with prescription drugs.

3 Types of Drug Interactions

  • Pharmacodynamic — Two drugs act on the same receptor, amplifying or canceling each other's effects
  • Pharmacokinetic — One drug affects the absorption, distribution, metabolism, or excretion of another (CYP450 enzyme interactions are common)
  • Physicochemical — Drugs bind together, reducing efficacy or forming toxic compounds

Seek Immediate Medical Attention If You Experience:

Difficulty breathing or chest painSevere dizziness or faintingUnusual bleeding or bruisingSevere nausea, vomiting, or stomach painJaundice (yellowing of skin or eyes)Severe hives or swellingSudden muscle pain or weaknessConfusion or loss of consciousness

Food & Drug Interactions

  • Grapefruit — Inhibits CYP3A4 enzymes, raising blood levels of statins, calcium channel blockers, and immunosuppressants
  • Alcohol — Interacts with most drugs including sedatives, pain relievers, and blood thinners; increases liver burden
  • Dairy & Calcium — Impairs absorption of tetracyclines, quinolone antibiotics, and thyroid medications
  • Vitamin K-rich foods (leafy greens) — Weakens warfarin's blood-thinning effect; maintain consistent daily intake

Before Taking Any Medication

  • Tell your doctor or pharmacist about all medications you take (prescription, OTC, supplements, herbal products)
  • Disclose if you are pregnant or planning to become pregnant
  • Take medications with water — avoid juice, milk, or alcohol
  • Follow dosage instructions carefully — never double a missed dose
  • Complete the full course of antibiotics even if symptoms improve
This guide provides general educational information and does not constitute medical advice. For personalized medication guidance, consult your doctor or pharmacist.
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