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Warfarin + Ibuprofen
Can you take these together?

🇺🇸 Based on FDA Data · Free
🚨
Do Not Combine
Warfarin + Ibuprofen

These medications are contraindicated. Do not take together without medical supervision.

📊 Data Sources
🇺🇸FDA openFDA API — Drug interaction data sourced from the U.S. Food & Drug Administration's official drug label database (openFDA). The same data used by U.S. healthcare professionals. FDA official site →
🇰🇷MFDS DUR API (Korea) — Contraindication data from South Korea's Ministry of Food and Drug Safety (MFDS) Drug Utilization Review public API. Covers 44,000+ medications. MFDS official site →

⚕️ This information is for reference only and does not constitute medical advice. Always consult a doctor or pharmacist before taking medications.

🔍 Check Another Combination
💊 Drug Information
Anticoagulant (Blood Thinner)Warfarin(Warfarin (Coumadin))

Warfarin is a prescription anticoagulant ("blood thinner") used to prevent and treat blood clots. It is prescribed for atrial fibrillation, deep vein thrombosis, pulmonary embolism, and artificial heart valves.

🔬 How It Works

Warfarin inhibits the synthesis of vitamin K-dependent clotting factors (II, VII, IX, X), slowing blood clot formation. It has a narrow therapeutic range, requiring regular INR (International Normalized Ratio) monitoring.

💡 Common Uses
  • Atrial fibrillation (stroke prevention)
  • Deep vein thrombosis (DVT) treatment and prevention
  • Pulmonary embolism treatment
  • Mechanical heart valve protection
⚡ Side Effects
  • Bleeding (gums, nose, urine, stool)
  • Serious internal bleeding with overdose
  • Rare skin necrosis
  • Osteoporosis with long-term use
⚠ Caution: Extensive drug and food interactions. Regular INR monitoring required. Report any unusual bleeding immediately.
NSAID / Anti-inflammatoryIbuprofen(Ibuprofen)

Ibuprofen (Advil, Motrin) is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain, fever, and inflammation. It is commonly used for headaches, toothaches, back pain, menstrual cramps, and arthritis.

🔬 How It Works

Ibuprofen inhibits cyclooxygenase (COX-1 and COX-2) enzymes, which reduces the production of prostaglandins — compounds that cause pain, inflammation, and fever. Its anti-inflammatory action makes it more effective than acetaminophen for inflammatory conditions.

💡 Common Uses
  • Headache and dental pain
  • Menstrual cramps
  • Muscle and joint pain
  • Fever reduction
  • Arthritis and rheumatic conditions
  • Sprains and strains
⚡ Side Effects
  • Stomach upset, heartburn, and gastric ulcers (especially on empty stomach)
  • Kidney function impairment (with long-term use)
  • Increased cardiovascular risk (high dose, long-term)
  • Fluid retention and elevated blood pressure
⚠ Caution: Take with food to reduce GI upset. Avoid in kidney disease, pregnancy (especially 3rd trimester), and with other NSAIDs.

💊 Drug Interaction Safety Guide

What is a Drug Interaction?

A drug interaction occurs when one medication affects the activity of another when taken simultaneously. This can increase or decrease the effectiveness of a drug, or cause unexpected side effects. Over-the-counter medications, supplements, and even foods can also interact with prescription drugs.

3 Types of Drug Interactions

  • Pharmacodynamic — Two drugs act on the same receptor, amplifying or canceling each other's effects
  • Pharmacokinetic — One drug affects the absorption, distribution, metabolism, or excretion of another (CYP450 enzyme interactions are common)
  • Physicochemical — Drugs bind together, reducing efficacy or forming toxic compounds

Seek Immediate Medical Attention If You Experience:

Difficulty breathing or chest painSevere dizziness or faintingUnusual bleeding or bruisingSevere nausea, vomiting, or stomach painJaundice (yellowing of skin or eyes)Severe hives or swellingSudden muscle pain or weaknessConfusion or loss of consciousness

Food & Drug Interactions

  • Grapefruit — Inhibits CYP3A4 enzymes, raising blood levels of statins, calcium channel blockers, and immunosuppressants
  • Alcohol — Interacts with most drugs including sedatives, pain relievers, and blood thinners; increases liver burden
  • Dairy & Calcium — Impairs absorption of tetracyclines, quinolone antibiotics, and thyroid medications
  • Vitamin K-rich foods (leafy greens) — Weakens warfarin's blood-thinning effect; maintain consistent daily intake

Before Taking Any Medication

  • Tell your doctor or pharmacist about all medications you take (prescription, OTC, supplements, herbal products)
  • Disclose if you are pregnant or planning to become pregnant
  • Take medications with water — avoid juice, milk, or alcohol
  • Follow dosage instructions carefully — never double a missed dose
  • Complete the full course of antibiotics even if symptoms improve
This guide provides general educational information and does not constitute medical advice. For personalized medication guidance, consult your doctor or pharmacist.
Frequently Checked Combinations
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